“Post-transcriptional gene regulation by the m6A-mRNA/YTHDF axis shapes plant architecture”
N6-methyladenosine (m6A) in mRNA is a key element of post-transcriptional gene regulation in eukaryotes, necessary for embryonic and post-embryonic development in plants and mammals. Some important effects of m6A are mediated by YTHDF proteins, a set of cytoplasmic RNA-binding proteins that specifically recognize m6A in mRNAs to modulate their stability and translatability. In this seminar, I will show how ETC2-4, three of the eleven YTHDF proteins, regulate the proliferation of stem cells in young organ primordia by m6A modifications.
