“RNA STRUCTURE: A HIDDEN REGULATOR IN LIVING CELLS”
RNA structure plays an important role in the post-transcriptional regulations of gene expression. The Ding group has been studying the functional roles of RNA structure in diverse biological processes such as mRNA processing (splicing and polyadenylation), translation and RNA degradation. The Ding group has also developed new methods to reveal the existence of tertiary RNA G-quadruplex structures in eukaryotes and uncovered that RNA G-quadruplex structure serves as a molecular marker to facilitate plant adaptation to the cold during evolution. Recently, the Ding group has developed the single-molecule RNA structure profiling method and revealed the functional importance of RNA structure in long noncoding RNAs.
Biografy: I obtained my PhD degree from the John Innes Centre in 2009. From 2010-2013, I am a joint postdoc between Prof. Philip Bevilacqua’s and Prof. Sarah Assmann’s groups at the Pennsylvania State University. I started the tenure track group leader position at the John Innes Centre in 2014 and obtained the tenure in 2019. I am currently also the honorary group leader at the Babraham Institute in Cambridge and the honorary associate professor at the University of East Anglia. My lab is working on the RNA structure functionalities in living cells.
REFERENCES:
* “Yang, Minglei; Zhu, Pan; Cheema, Jitender; Bloomer, Rebecca; Mikulski, Pawel; Liu, Qi; Zhang, Yueying; Dean, Caroline; Ding, Yiliang; “,In vivo single-molecule analysis reveals COOLAIR RNA structural diversity,Nature,1-6,2022
* “Yang, Xiaofei; Yu, Haopeng; Duncan, Susan; Zhang, Yueying; Cheema, Jitender; Miller, J Benjamin; Zhang, Jie; Kwok, Chun Kit; Zhang, Huakun; Ding, Yiliang; “,RNA G-quadruplex structure contributes to cold adaptation in plants, Nature Communications, 2022
* “Liu, Zhenshan; Liu, Qi; Yang, Xiaofei; Zhang, Yueying; Norris, Matthew; Chen, Xiaoxi; Cheema, Jitender; Zhang, Huakun; Ding, Yiliang; “,In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants,Genome biology,22,1,1-22,2021
* “Yang, Xiaofei; Cheema, Jitender; Zhang, Yueying; Deng, Hongjing; Duncan, Susan; Umar, Mubarak Ishaq; Zhao, Jieyu; Liu, Qi; Cao, Xiaofeng; Kwok, Chun Kit; “,RNA G-quadruplex structures exist and function in vivo in plants,Genome biology,21,1,1-23,2020
* “Yang, Minglei; Woolfenden, Hugh C; Zhang, Yueying; Fang, Xiaofeng; Liu, Qi; Vigh, Maria L; Cheema, Jitender; Yang, Xiaofei; Norris, Matthew; Yu, Sha; “,Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo,Nucleic Acids Research,48,15,8767-8781,2020
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