“Languages of the Non-coding Genome”
Genomes are the blueprints of life: the genomic DNA sequences contain the instructions for the formation of a given species. DNA sequence polymorphisms between individuals of the same species offer a hypothesis to understand the molecular bases of fitness differences. However, many polymorphisms are located in parts of the genome that we poorly understand: the non-coding genome. While polymorphisms that change the protein sequence offer a sufficiently clear path forward, my seminar outlines approaches and solutions to understand the non-coding genome. Results from my laboratory illustrate different molecular mechanisms of how the non-coding genome promotes organismal fitness. The results from my lab highlight different ways of how the non-coding genome communicates functional information, with intriguing implications for current models explaining non-coding genome conservation and function.
Some recent publications:
LncRNA FLAIL affects alternative splicing and represses flowering in Arabidopsis.
Jin Y, Ivanov M, Dittrich AN, Nelson AD, Marquardt S.EMBO J. 2023 Jun 1;42(11):e110921. doi: 10.15252/embj.2022110921. Epub 2023 Apr 13.
Functional variation in the non-coding genome: molecular implications for food security.
Gullotta G, Korte A, Marquardt S.J Exp Bot. 2023 Apr 9;74(7):2338-2351. doi: 10.1093/jxb/erac395.
Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis.
Thomas QA, Ard R, Liu J, Li B, Wang J, Pelechano V, Marquardt S.Nat Commun. 2020 May 22;11(1):2589. doi: 10.1038/s41467-020-16390-7.
If anyone is interested in meeting with the speaker, please contact Javi Gallego