Dr. José Gallego. Centro de Investigación Traslacional San Alberto Magno. Universidad Católica de Valencia
“Pathogenic virus RNA: conformation, function and therapeutic targeting”
In this lecture, case studies of RNA motifs playing key roles in the replication cycle of hepatitis C, HIV-1 and SARS-CoV-2 will be discussed. I will describe the nuclear magnetic resonance, X-ray scattering and fluorescence methods used in my laboratory to study their three-dimensional shape, and how we think that these RNA conformations play a role in biological function. In several cases, we are interrogating these RNA motifs with small molecules in an attempt to discover new antiviral agents. I will provide specific examples, and will discuss the strategies and chemical challenges involved in the RNA targeting field.
Please find attached some recent works:
- The low-resolution structural models of hepatitis C virus RNA subdomain 5BSL3.2 and its distal complex with domain 3 X point to conserved regulatory mechanisms within the Flaviviridae family
- SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules
- Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix
If anyone is interested in meeting with Dr. Gallego, please contact Dr. Darós (jadaros@ibmcp.upv.es)
