Seminar Dr. José Gallego. Friday February 10th 12:30h. Conference Hall 3rd floor

Fecha y Hora del Seminario: February 10, 2023 12:30 pm

Dr. José Gallego. Centro de Investigación Traslacional San Alberto MagnoUniversidad Católica de Valencia

“Pathogenic virus RNA: conformation, function and therapeutic targeting”

In this lecture, case studies of RNA motifs playing key roles in the replication cycle of hepatitis C, HIV-1 and SARS-CoV-2 will be discussed.  I will describe the nuclear magnetic resonance, X-ray scattering and fluorescence methods used in my laboratory to study their three-dimensional shape, and how we think that these RNA conformations play a role in biological function. In several cases, we are interrogating these RNA motifs with small molecules in an attempt to discover new antiviral agents. I will provide specific examples, and will discuss the strategies and chemical challenges involved in the RNA targeting field.

Please find attached some recent works:

If anyone is interested in meeting with Dr. Gallego, please contact Dr. Darós (jadaros@ibmcp.upv.es)

 

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