de la Peña del Rivero

Teléfono: +34 963 877 915
Investigador en Plantilla
Científico Titular CSIC
ResearcherID: D-5001-2009


I am currently Tenured Research Scientist at the Spanish National Research Council (CSIC). My research interests are focused on the capabilities of the RNAs as both genomic (RNA virus/viroid genomes and retroelements) and catalytic molecules (Ribozymes). My group has previously unveiled that small ribozymes are conserved from bacteria to human genomes, changing the vision about the catalytic capabilities of most transcriptomes. Following bioinformatics and wet lab approaches, we have dissected the biological roles of some of these ribozymes in new forms of DNA retrotransposition through small circRNAs. More recently, we have characterized novel ribozymes in Delta-like viruses of animals, results that in combination with the Serratus platform have allowed us to discover thousands of novel infectious agents of circRNA with ribozymes as part of a new virus realm called Ribozyviria.

Publicaciones destacadas

  • Edgar R, Taylor J, Lin V, Altman T, Barbera P, Meleshko D, Lohr D, Novakovsky G, Buchfink B, Al-Shayeb B, Banfield JF, de la Peña M., Korobeynikov A, Chikhi R, Babaian A (2022) Petabase-scale sequence alignment catalyses viral discovery. Nature 602:142-147 (all authors contributed equally) doi: 10.1038/s41586-021-04332-2
  • de la Peña, M. (2021) Small Self‐Cleaving Ribozymes in the Genomes of Vertebrates. Ribozymes Vol 2, Editorial Wiley-VCH GmbH (Chapter 11, Editors: S. Müller, B. Masquida y W. Winkler) doi: 10.1002/9783527814527.ch11
  • de la Peña, M. , Ceprián, R., Casey, J.L., Cervera, A. (2021) Hepatitis delta virus-like circular RNAs from diverse metazoans encode conserved hammerhead ribozymes. Virus Evol 7(1): veab016
  • de la Peña, M. , Ceprián, R., Cervera, A. (2020) A singular and widespread group of mobile genetic elements: RNA circles with autocatalytic ribozymes. Cells, 9(12): 2555
  • Cervera, A., de la Peña, M. (2020) Small circRNAs with self-cleaving ribozymes are highly expressed in diverse metazoan transcriptomes. Nucl Acids Res, 48(9):5054-64
  • de la Peña M. (2018) Circular RNAs Biogenesis in Eukaryotes Through Self-Cleaving Hammerhead Ribozymes. Adv Exp Med Biol. 1087:53-63. doi: 10.1007/978-981-13-1426-1_5
  • Rico P., Rodrigo-Navarro A., de la Peña M., Moulisova V., Costell M., Salmerón-Sánchez M. (2018) Simultaneous Boron Ion-Channel/Growth Factor Receptor Activation for Enhanced Vascularization. Adv Biosys.1800220. doi: 10.1002/adbi.201800220
  • Alquézar B, Rodríguez A, de la Peña M., Peña L (2017) Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis. Front Plant Sci. 8:1481. doi: 10.3389/fpls.2017.01481
  • de la Peña M., Cervera A (2017) Circular RNAs with hammerhead ribozymes encoded in eukaryotic genomes: The enemy at home. RNA Biol. 14(8):985-991. doi: 10.1080/15476286.2017.1321730.
  • de la Peña M., García-Robles I, Cervera A (2017) The Hammerhead Ribozyme: A Long History for a Short RNA. Molecules. 22(1). pii: E78. doi: 10.3390/molecules22010078.
  • Cervera A, Urbina D, de la Peña M. (2016) Retrozymes are a unique family of non-autonomous retrotransposons with hammerhead ribozymes that propagate in plants through circular RNAs. Genome Biol. 17(1):135. doi: 10.1186/s13059-016-1002-4.
  • Cervera A, de la Peña M. (2014) Eukaryotic penelope-like retroelements encode hammerhead ribozyme motifs. Mol Biol Evol. 31(11):2941-7. doi: 10.1093/molbev/msu232.
  • Kyrieleis OJ, Chang J, de la Peña M., Shuman S, Cusack S (2014) Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus. Structure. 2014 Mar 4;22(3):452-65. doi: 10.1016/j.str.2013.12.014.
  • García-Robles I, Sánchez-Navarro J, de la Peña M. (2012) Intronic hammerhead ribozymes in mRNA biogenesis. Biol Chem. 393(11):1317-26. doi: 10.1515/hsz-2012-0223.
  • Hammann C, Luptak A, Perreault J, de la Peña M. (2012) The ubiquitous hammerhead ribozyme. RNA. 18(5):871-85. doi: 10.1261/rna.031401.111.
  • Kalweit A, Przybilski R, Seehafer C, de la Peña M., Hammann C (2012) Characterization of hammerhead ribozyme reactionsMethods Mol Biol. 848:5-20. doi: 10.1007/ la Peña M., García-Robles I (2010) Ubiquitous presence of the hammerhead ribozyme motif along the tree of lifeRNA. 16(10):1943-50. doi: 10.1261/rna.2130310.
  • de la Peña M., García-Robles I (2010) Intronic hammerhead ribozymes are ultraconserved in the human genomeEMBO Rep. 11(9):711-6. doi: 10.1038/embor.2010.100.
  • de la Peña M., Dufour D, Gallego J (2009) Three-way RNA junctions with remote tertiary contacts: a recurrent and highly versatile foldRNA. 15(11):1949-64. doi: 10.1261/rna.1889509.
  • Wulff BB, Heese A, Tomlinson-Buhot L, Jones DA, de la Peña M., Jones JD (2009) The major specificity-determining amino acids of the tomato Cf-9 disease resistance protein are at hypervariable solvent-exposed positions in the central leucine-rich repeatsMol Plant Microbe Interact. 22(10):1203-13. doi: 10.1094/MPMI-22-10-1203.