Javier

Gallego Bartolomé

Teléfono: +34 963 877 856
Extensión: 78675
Career Track Fellow
Investigador Ramón y Cajal
Localización: lab 2.05 https://jagalbar.wixsite.com/gallego-bartolome

Biografía

I graduated as Agronomical Engineer at the Polytechnic University of Valencia (UPV) in 2004. Then I joined the lab of Drs Blázquez and Alabadí (IBMCP, Valencia, Spain), where I studied different molecular mechanisms by which the plant hormone Gibberellins (GAs) interacts with other hormones to control gene expression. Once I defended my PhD in 2011, I did a short postdoc in the Chory lab (The Salk Institute, La Jolla, USA), and then I moved, in 2013, to the Jacobsen lab (UCLA, Los Angeles, US), where I worked on targeted manipulation of DNA methylation in plants and studied mechanistic aspects of the de-novo silencing machinery in plants. At the IBMCP,  my team is interested in the epigenetic regulation of gene expression in plants.

Publicaciones destacadas

Selected publications:

(* first author)

  1. Liu W*, Gallego-Bartolomé J*, Zhou Y, Zhong Z, Wang M, Wongpalee SP, Gardiner J, Feng S, Kuo PH, Jacobsen SE (2021). Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. Nat Commun. 2021 May 25;12(1):3130.
  2. Zhong Z, Feng S, Duttke SH, Potok ME, Zhang Y, Gallego-Bartolomé J, Liu W, Jacobsen SE. (2021). DNA methylation-linked chromatin accessibility affects genomic architecture in Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2023347118
  3. Gallego-Bartolomé J (2020). DNA methylation in plants: mechanisms and tools for targeted    manipulation. New Pythologist. doi.org/10.1111/nph.16529
  4. Wongpalee SP*, Liu S*, Gallego-Bartolomé J*, Leitner A, Aebersold R, Liu W, Yen L, Nohales MA, Kuo PH, Vashisht AA, Wohlschlegel JA, Feng S, Kay SA, Zhou ZH, Jacobsen SE. (2019). CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nat Commun. 2019 Sep 2;10(1):3916. (*equal contribution)
  5. Papikian A, Liu W, Gallego-Bartolomé J, Jacobsen SE. (2019). Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems. Nat Commun. 2019 Feb 13;10(1):729.
  6. Gallego-Bartolomé J, Liu W, Kuo PH, Feng S, Ghoshal B, Gardiner J, Zhao JM, Park SY, Chory J, Jacobsen SE. (2018). Co-targeting RNA Polymerases IV and V promotes efficient de novo DNA methylation in Arabidopsis. Cell. 2019 Feb 21;176(5):1068-1082.e19.
  7. Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F, Jacobsen SE. (2018). A DNA methylation reader complex that enhances gene transcription. Science. 2018 Dec 7;362(6419):1182-1186.
  8. Gallego-Bartolomé J*, Gardiner J*, Liu W*, Papikian A*, Ghoshal B, Kuo HY, Zhao JM, Segal DJ, Jacobsen SE (2017). Targeted DNA demethylation of the Arabidopsis genome using the Human TET1 catalytic domain. Proc Natl Acad Sci U S A. Feb 27;115(9):E2125-E2134. (*equal contribution).
  9. Zhong X, Du J, Hale CJ, Feng S, Gallego-Bartolome J, Vashisht A, Chory J, Wohlschlegel J, Patel D and Jacobsen SE (2014). Molecular mechanism of action of plant DRM de novo DNA methyltransferases. Cell. 2014 May 22;157(5):1050-60
  10. Gallego-Bartolomé J, Minguet EG, Grau-Enguix F, Abbas M, Locascio A, Thomas SG, Alabadí D, Blázquez MA. (2012) Molecular mechanism for the interaction between gibberellin and brassinosteroid signaling pathways in Arabidopsis. Proc Natl Acad Sci U S A. Aug 14;109(33):13446-51. doi: 10.1073/pnas.1119992109. Epub 2012 Jul 30.
  11. Gallego-Bartolomé J, Alabadí D, Blázquez MA. (2011) DELLA-Induced Early Transcriptional Changes during Etiolated Development in Arabidopsis thaliana. PLoS One 6(8):e23918
  12. Gallego-Bartolomé J, Minguet EG, Marín JA, Prat S, Blázquez MA, Alabadí D. (2010)Transcriptional diversification and functional conservation between DELLA proteins in Arabidopsis. Mol Biol Evol. 27: 1247-1256.