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Discovering

Pedro Luis

Rodriguez Egea

Email: prodriguez@ibmcp.upv.es
Telephone: +34 963 877 860
Extension: 77860
Investigador en Plantilla
Profesor de Investigación CSIC
Group: Abscisic Acid Signaling
ResearcherID: K-4605-2014
ORCID: 0000-0002-5886-9425
Location: Lab. 2.04

Biography

Education: Ph. D. in Biochemistry and Molecular Biology (1994), Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain Career: ●Staff CSIC since 2006. Instituto de Biologia Molecular y Celular de Plantas. In 2009 promoted to Research Scientist. In 2016 promoted to Research Professor. ●Assistant Professor of Biochemistry and Molecular Biology, 2003-2006. Universidad Politecnica de Valencia ●Ramon y Cajal Postdoctoral fellow, 1998-2003. Laboratory of Prof. Ramon Serrano, Universidad Politecnica de Valencia. ●EMBO postdoctoral fellow, 1995-1997. Laboratory of Prof. Erwin Grill, ETH Zurich, Switzerland/ TU Munich, Germany. Author of >100 articles, 4 patents, participation in 33 projects (20 as PI), Associated Editor in Molecular Plant. Dr. Rodriguez is a leader in ABA signaling, with particular emphasis on the biotechnological potential of the pathway for improving plant tolerance to drought and salinity. He has played a key role in the discovery and characterization of the new family of PYR/PYL ABA receptors and their connection with PP2Cs and SnRK2s.

Featured Posts

  • Alberto Coego, Jose Julian, Jorge Lozano-Juste, Gaston A. Pizzio, Abdulwahed F. Alrefaei and Pedro L. Rodriguez (2021). Ubiquitylation of ABA receptors and protein phosphatase 2C coreceptors to modulate ABA signaling and stress response. Int. J. Mol. Sci 22, 7103.
  • Rui Miao, Wei Yuan, Yue Wang, Irene García-Maquilón, Xiaolin Dang, Suchang Huang, Ying Li, Jianhua Zhang, Yiyong Zhu, Pedro L. Rodriguez, Weifeng Xu (2021). Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane   H+-ATPase 2. Science Advances 7 (12): eabd4113
  • Irene García-Maquilón, Pedro L. Rodriguez, Aditya S. Vaidya, Jorge Lozano-Juste (2021). A luciferase reporter assay to identify chemical activators of ABA signaling. Plant Chemical Genomics Methods Mol Biol. 2021;2213:113-121. doi: 10.1007/978-1-0716-0954-5_10
  • Jorge Lozano-Juste, Irene García-Maquilón, José Brea, Rocío Piña, Armando Albert, Pedro L. Rodriguez, María Isabel Loza. Plant Chemical Genomics (2021). Identification of ABA receptor agonists using a multiplexed high-throughput chemical screening. Methods Mol Biol. 2021;2213:99-111. doi: 10.1007/978-1-0716-0954-5_9.    
  • Garcia-Maquilon,I., Coego,A., Lozano-Juste,J., Messerer,M., de Ollas,C., Julian,J., Ruiz-Partida,R., Pizzio,G., Belda-Palazon,B., Gomez-Cadenas,A., Mayer,K.F.X., Geiger,D., Alquraishi,S.A., Alrefaei,A.F., Ache,P., Hedrich,R. and Rodriguez,P.L. (2021). PYL8 ABA receptors of Phoenix dactylifera play a crucial role in response to abiotic stress and are stabilized by ABA. J.Exp.Bot. 72(2):757-774
  • Belda-Palazon,B., Adamo,M., Valerio,C., Ferreira,L.J., Confraria,A., Reis-Barata,D., Rodrigues,A., Meyer,C., Rodriguez,P.L. and Baena-Gonzalez,E. (2020). A dual function of SnRK2 kinases in the regulation of SnRK1 and plant growth. Nature Plants 6(11):1345-1353
  • Lozano-Juste,J., Alrefaei,A.F. and Rodriguez,P.L. (2020). Plant Osmotic Stress Signaling: MAPKKKs Meet SnRK2s. Trends Plant Sci. Dec;25(12):1179-1182
  • Garcia-Andrade,J., Gonzalez,B., Gonzalez-Guzman,M., Rodriguez,P.L. and Vera,P. (2020). The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor. Int. J. Mol. Sci. 21, E5852
  • Lozano-Juste,J., Garcia-Maquilon,I., Ruiz-Partida,R. and Rodriguez,P.L. (2020). Drug Discovery for Thirsty Crops. Trends Plant Sci. Sep;25(9):844-846
  • Belda-Palazon, B., and Rodriguez, P. L. (2020). Degradation of abscisic acid receptors through the endosomal pathway. Methods Mol Biol. 2177:35-48. Book “Plant Endosomes”: Methods and Protocols
  • Fernandez, M. A., Belda-Palazon, B., Julian, J., Coego, A., Lozano-Juste, J., Inigo, S., Rodriguez, L., Bueso, E., Goossens, A., and Rodriguez, P. L. (2020). RBR-type E3 ligases and the Ub-conjugating enzyme UBC26 regulate ABA receptor levels and signaling. Plant Physiol. 182(4):1723-1742
  • Dittrich, M., Mueller, H. M., Bauer, H., Peirats-Llobet, M., Rodriguez, P. L., Geilfus, C. M., Carpentier, S. C., Al Rasheid, K. A. S., Kollist, H., Merilo, E., Herrmann, J., Muller, T., Ache, P., Hetherington, A. M., and Hedrich, R. (2019). The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration. Nature Plants 5(9), 1002-1011.
  • Garcia-Leon, M., Cuyas, L., El-Moneim, D., Rodriguez, L., Belda-Palazon, B., Fernandez, Y., Roux, B., Zamarreño, A.M., Garcia-Mina, J.M., Nussaume, L., Rodriguez, P.L., Paz-Ares, J., Leonhardt, N., and Rubio, V. (2019). Arabidopsis ALIX Regulates Stomatal Aperture and Turnover of Abscisic Acid Receptors. Plant Cell 31(10):2411-2429.
  • Julian, J., Coego, A., Lozano-Juste, J., Lechner, E., Wu, Q., Zhang, X., Merilo, E., Belda-Palazon, B., Park, S. Y., Cutler, S. R., An, C., Genschik, P., and Rodriguez, P. L. (2019). The MATH-BTB BPM3 and BPM5 subunits of Cullin3-RING E3 ubiquitin ligases target PP2CA and other clade A PP2Cs for degradation. Proc.Natl.Acad.Sci.USA. 116(31):15725-15734
  • Lozano-Juste, J., Masi, M., Cimmino, A., Clement, S., Fernandez, M. A., Antoni, R., Meyer, S., Rodriguez, P. L., and Evidente, A. (2019). The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination. J.Exp.Bot. 70(19):5487-5494.
  • Li, H., Li, Y., Zhao, Q., Li, T., Wei, J., Li, B., Shen, W., Yang, C., Zeng, Y., Rodriguez, P. L., Zhao, Y., Jiang, L., Wang, X., and Gao, C. (2019). The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling. Nature Plants. 5(5):512-524.
  • Pedro L. Rodriguez, Jorge Lozano-Juste and Armando Albert. PYR/PYL/RCAR ABA receptors (2019). Advances in Botanical Research, Abscisic Acid in Plants, volume 92, pages 51-82. Edited by M. Seo and A. Marion-Poll. Elsevier. doi:10.1016/bs.abr.2019.05.003
  • Belda-Palazon, B., Julian, J., Coego, A., Wu, Q., Zhang, X., Batistic, O., Alquraishi, S. A., Kudla, J., An, C., and Rodriguez, P. L. (2019). ABA inhibits myristoylation and induces shuttling of the RGLG1 E3 ligase to promote nuclear degradation of PP2CA. Plant J. doi10.1111/tpj.14274
  • Belda-Palazon, B., Gonzalez-Garcia, M. P., Lozano-Juste, J., Coego, A., Antoni, R., Julian, J., Peirats-Llobet, M., Rodriguez, L., Berbel, A., Dietrich, D., Fernandez, M. A., Madueno, F., Bennett, M. J., and Rodriguez, P. L. (2018). PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization-based mechanisms. Proc.Natl.Acad.Sci. U.S.A 115, E11857-E11863
  • Moreno-Alvero,M., Yunta,C., Gonzalez-Guzman,M., Lozano-Juste,J., Benavente,J.L., Arbona,V., Menendez,M., Martinez-Ripoll,M., Infantes,L., Gomez-Cadenas,A., Rodriguez,P.L.* and Albert,A.* (2017). Structure of Ligand-Bound Intermediates of Crop ABA Receptors Highlights PP2C as Necessary ABA Co-receptor. Molecular Plant 10, 1250-1253
  • Rodriguez PL (2016). ABA catabolism generates PA, a molecule able to activate a subset of ABA receptors. Molecular Plant 9, 1448-1450
  • Wu,Q., Zhang,X., Peirats-Llobet,M., Belda-Palazon,B., Wang,X., Cui,S., Yu,X., Rodriguez,P.L.* and An,C. *(2016). Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA. Plant Cell 28:2178-2196
  • Belda-Palazon,B., Rodriguez,L., Fernandez,M.A., Castillo,M.C., Anderson,E.A., Gao,C., Gonzalez-Guzman,M., Peirats-Llobet,M., Zhao,Q., De Winne,N., Gevaert,K., De Jaeger,G., Jiang,L., Leon,J., Mullen,R.T. and Rodriguez,P.L. (2016). FYVE1/FREE1 Interacts with the PYL4 ABA Receptor and Mediates its Delivery to the Vacuolar Degradation Pathway. Plant Cell 28:2291-2311
  • Antoni,R., Dietrich,D., Bennett,M.J. and Rodriguez,P.L. (2016). Hydrotropism: Analysis of the Root Response to a Moisture Gradient. Methods Mol. Biol. 1398, 3-9.
  • Diaz,M., Sanchez-Barrena,M.J., Gonzalez-Rubio,J.M., Rodriguez,L., Fernandez,D., Antoni,R., Yunta,C., Belda-Palazon,B., Gonzalez-Guzman,M., Peirats-Llobet,M., Menendez,M., Boskovic,J., Marquez,J.A., Rodriguez,P.L. and Albert,A. (2016). Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling. Proc.Natl.Acad.Sci.U.S.A  Jan 19;113(3):E396-405
  • Peirats-Llobet,M., Han,S.K., Gonzalez-Guzman,M., Jeong,C.W., Rodriguez,L., Belda-Palazon,B., Wagner,D. and Rodriguez,P.L. (2016). A direct link between abscisic acid sensing and the chromatin remodeling ATPase BRAHMA via core ABA signaling pathway components. Mol Plant. 9(1):136-47.
  • Rodriguez, P.L. and Lozano-Juste, J. (2015). Unnatural agrochemical ligands for engineered abscisic acid receptors. Trends in Plant Science 20(6):330-2.
  • Gonzalez-Guzman,M., Rodriguez,L., Lorenzo-Orts,L., Pons,C., Sarrion-Perdigones,A., Fernandez,M.A., Peirats-Llobet,M., Forment,J., Moreno-Alvero,M., Cutler,S.R., Albert,A., Granell,A. and Rodriguez,P.L. (2014). Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance. J Exp Bot  65, 4451-4464.
  • Bueso E, Rodriguez L, Lorenzo-Orts L, Gonzalez-Guzman M, Sayas E, Muñoz-Bertomeu J, Ibañez C, Serrano R, Rodriguez P.L. (2014) The single subunit RING-type E3 ubiquitin ligase RSL1 targets PYL4 and PYR1 ABA receptors in plasma membrane to modulate abscisic acid signaling. Plant J. 80, 1057-1071.
  • Rodriguez, L., Gonzalez-Guzman, M., Diaz, M., Rodrigues, A., Peirats-Llobet, M., Izquierdo-Garcia, A.C., Antoni, R., Marquez, J.A. Mulet, J.M. Albert, A. and Rodriguez P.L. (2014). C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane. Plant Cell 26, 26(12):4802-20
  • Pizzio, G.A., Rodriguez, L., Antoni, R., Gonzalez-Guzman, M., Yunta, C., Merilo, E., Kollist, H., Albert, A., Rodriguez P.L. (2013) The PYL4 A194T mutant uncovers a key role of PYL4-PP2CA interaction for ABA signaling and plant drought resistance. Plant Physiology 163: 441-455.
  • Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Peirats-Llobet, M., Pizzio, G.A., Fernandez, M.A., De Winne N., De Jaeger G., Dietrich, D., Bennett M.J., Rodriguez P.L (2013). PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root. Plant Physiology 161: 931-941.
  • Gonzalez-Guzman, M., Pizzio, G.A, Antoni, R., Vera-Sirera, F., Merilo, E., Bassel, G.W., Fernandez, M.A., Holdsworth, M., Perez-Amador, M.A., Kollist, H. and Rodriguez, P.L (2012). Abscisic acid perception via PYR/PYL/RCAR receptors plays a major role to regulate stomatal aperture and ABA transcriptional response. Plant Cell 24: 2483-2496.
  • Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Rodrigues, A., Pizzio, G.A. and  Rodriguez, P.L (2012). Selective inhibition of clade A phosphatases type 2C by PYR/RCAR/RCAR abscisic acid receptors Plant Physiology 158, 970-980.
  • Dupeux, F., Antoni, R., Betz, K., Santiago, J., Gonzalez-Guzman, M., Rodriguez, L., Rubio, S., Park, S-Y., Cutler, S.R., Rodriguez, P.L* and Marquez, J.A. (2011). Modulation of ABA signaling in vivo by an engineered receptor-insensitive PP2C allele. Plant Physiology 156, 106-116.
  • Cutler, S.R., Rodriguez, P.L., Finkelstein, R.R., Abrams, S.R. (2010). Abscisic acid: emergence of a core signaling network. Annu. Rev. Plant Biol. 61, 651-679.
  • Santiago, J., Rodrigues, A., Saez, A., Rubio, S., Antoni, R., Park, S-Y., Dupeux, F., Marquez, J.A., Cutler, S.R. and Rodriguez, P.L. (2009). Modulation of drought resistance by the abscisic acid-receptor PYL5 through inhibition of clade A PP2Cs. Plant J 60, 575-588.
  • Rubio, S., Rodrigues, A., Saez, A., Dizon, M.B., Galle, A., Kim, T., Santiago, J., Flexas, J., Schroeder, J.I.S. and Rodriguez, P.L. (2009). Triple loss-of-function of protein phosphatases type 2C leads to partial constitutive response to endogenous ABA. Plant Physiology 150, 1345-1355.
  • Santiago, J., Dupeux, F., Round, A., Antoni, R., Park, S-Y., Jamin, M., Cutler, S.R., Rodriguez, P.L. and Marquez, J.A. (2009). The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 462, 660-664
  • Fujii, H., Chinnusamy, V., Rodrigues, A., Rubio, S., Antoni, R., Park, S-Y., Cutler, S.R., Sheen, J., Rodriguez, P.L. and Zhu, J-K. (2009). In vitro reconstitution of an ABA signalling pathway. Nature 462, 665-668.
  • Park, S-Y., Fung, P., Nishimura, N., Jensen, D.R., Fujii, H., Zhao, Y., Lumba, S., Santiago, J., Rodrigues, A., Chow, T-S., Alfred, S.E., Bonetta, D., Finkelstein, R., Provart, N.J., Desveaux, D., Rodriguez, P.L., McCourt, P., Zhu, J-K, Schroeder, J.I., Volkman, B.F. and Cutler, S.R. (2009). Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of ABA-binding START proteins. Science 324, 1068-1071.
  • Saez, A., Rodrigues, A, Santiago, J., Rubio, S. and Rodríguez, P.L. (2008). HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin remodeling complexes. Plant Cell 20, 2972-2988.
  • Saez, A., Robert, N., Maktabi, M., Schroeder, J.I, Serrano, R. and Rodriguez, P.L. (2006). Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Plant Physiol 141, 1389-1399.
  • Saez, A., Apostolova, N., Gonzalez-Guzman, M.,  Gonzalez-Garcia, M.P., Nicolas, C., Lorenzo, O. and Rodriguez, P.L. (2004). Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling. Plant J 37, 354-369.
  • Gonzalez-Guzman, M., Apostolova, N., Belles, J.M., Barrero, J.M., Piqueras, P., Ponce, M.R., Micol, J.L., Serrano, R. and Rodriguez, P.L. (2002). The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde. Plant Cell 14, 1833-1846.