“Small peptides, a game-changing strategy for synthetic biology”:
Peptide-based drugs have gained a wide range of applications in biotechnology, making necessary to explore new routes that go beyond traditional peptide identification strategies. Here we describe the construction of a combinatorial genetic-based library [8x(NNK)] able to encode millions of different cyclic peptides, at once. The library (CYCLIC) can be screened by using the GAL4-based yeast two-hybrid assay, which enables to detect protein-peptide interactions in vivo. Cyclic peptides show higher stability and permeability of biological membranes as well as higher affinity for the protein target, making them preferable to the linear counterparts. The effectiveness of the CYCLIC-based technology will be described together with some examples of its applications in plant biotechnology
Llega el nuevo ciclo de SeminariosIBMCP 24/25
18 de September de 2024
No Comments
¡Cómo cada curso ya están aquí nuestros seminarios! A lo largo de este semestre nos visitarán diferentes investigadores e investigadoras para contarnos y actualizarnos lo
