GROUP: Vera´s Lab

Nuestra investigación orbita alrededor de dos temáticas fundamentales. Una de ellas hace referencia al entendimiento de los mecanismos moleculares y la identificación de genes que median en el establecimiento de respuestas adaptativas de las plantas a los cambios del entorno en el que crecen. Constituye un eje fundamental dentro de esta temática el entender los mecanismos de resistencia y susceptibilidad de las plantas a las agresiones patogénicas. Para tal fin utilizamos el sistema modelo de Arabidopsis como sistema experimental, con el consiguiente traslado y aplicación del conocimiento científico obtenido a otras especies vegetales de mayor relevancia agronómica y también industrial. Para apoyar estos estudios hemos creado una plataforma de genética química que pretendemos instrumentalizar para identificar moléculas agonistas y antagonistas de procesos relacionados con la respuestas adaptativas de las plantas.

La otra temática a la que también estamos dirigiendo recursos y esfuerzos de investigación está relacionada con la realización de aproximaciones genómicas y genéticas de alto calado en cultivos energéticos de referencia. Con ello pretendemos maximizar la producción de moléculas de alto valor añadido para el sector de las energías renovables, en particular en el de la Bioenergía, con el fin de contribuir a la producción de biocombustibles de segunda y tercera generación a partir de materia prima vegetal. En particular estamos desarrollando una aproximación de mejora genética acelerada del cultivo de Euphrobia lathyris L. así como una aproximación genético molecular para el mejor entendiendo las bases moleculares y celulares de la diferenciación de células laticíferas que actúan como despensa energética de esta especie y son las portadora de los “energy carriers” de esta especie.

LÍNEAS DE INVESTIGACIÓN

• Mecanismos de Adaptación de las Plantas a Cambios Medioambientales.
• Biotecnología de Cultivos Energéticos.

• Escaray, F.J., Felipo-Benavent, A., Vera, P. (2022)

Linking plant metabolism and immunity through methionine biosyntehesis

Molecular Plant 15 (1): 6-8

______________________________________________________________________________________________________

• Castelblanque L., Garcıía-Andrade J., Martínez-Arias C., Rodríguez J.J., Escaray F.J., Aguilar-Fenollosa E., Jaques J.A., and Vera P (2021)

Opposing Roles of Plant Laticifer Cells in the Resistance to Insect Herbivores and Fungal Pathogens

Plant Comm. 2 (3), 100112

______________________________________________________________________________________________________

• García-Andrade,J., Gonzalez, B., Gonzalez-Guzman, M., Rodriguez, P.L., and Vera, P. (2020)

The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor. 

Int. J. Mol. Sci. https://doi.org/10.3390/ijms21165852

_____________________________________________________________________________________________________

• GONZÁLEZ, B. and VERA, P (2019)

Folate Metabolism Interferes Plant Immunity through 1C Methionine Synthase-directed Genome-wide DNA Methylation Enhancement

Mol. Plant. doi.org/10.1016/j.molp.2019.04.013

_____________________________________________________________________________________________________

• Ramírez V, González B, López A, Castelló MJ, Gila MJ, Zheng B, Chen P, Vera P (2018)

A 2´-O-methyltransferase responsible for tRNA Anticodon Modification is Pivotal for Resistance to Pseudomonas syringae DC3000 in Arabidopsis

Mol. Plant Microb. Interact. 10.1094/MPMI-06-18-0148-R

______________________________________________________________________________________________________

• Castelblanque Lourdes, Balaguer Begoña, Marti Cristina, Orozco Marianela, Vera Pablo (2018)

LOL2 and LOL5 loci control latex production by laticifer cells in Euphorbia lathyris

New Phytologist. 10.1111/nph.15253

_____________________________________________________________________________________________________

• Schaller A; Stintzi A; Rivas S; Serrano I; Chichkova NV; Vartapetian AB; Martínez D; Guiamét JJ; Sueldo DJ; van der Hoorn RAL; Ramírez V; Vera P (2017)

From structure to function – a family portrait of plant subtilases

New Phytologist 218: 879–881

____________________________________________________________________________________________________

• Castelblanque L, Balaguer B, Martí C, Rodríguez JJ, Orozco M, Vera P. (2017)

Multiple facets of laticifer cells.

Plant Signalling & Behavior. 12(7): e1300743

_____________________________________________________________________________________________________

• Castelblanque L , Balaguer B , Martí C, Rodríguez JJ , Orozco M, Vera P (2016)

Novel Insights into the Organization of Laticifer Cells: A Cell Comprising a Unified Whole System

Plant Physiology 172: 1032-1044

______________________________________________________________________________________________________

• Dobón A, Canet JV, García-Andrade J, Angulo C, Neumetzler L, Persson S, Vera P (2015)

Novel Disease Susceptibility Factors for Fungal Necrotrophic Pathogens in Arabidopsis

PLoS Pathogens 11: e1004800

_____________________________________________________________________________________________________

• CarrascoJL, CastellóMJ, Naumann K, Lassowskat I, Navarrete-Gómez M, Scheel D, Vera P (2014)

Arabidopsis Protein Phosphatase DBP1 Nucleates a Protein Network with a Role in Regulating Plant Defense

PLoS ONE 9: e90734

_____________________________________________________________________________________________________

• Franco-Zorrilla JM, López-Vidriero I, Carrasco JL, Godoy M, Vera P, Solano R (2014)

DNA-binding specificities of plant transcription factors and their potential to define target genes

Proceedings of the National Academy of Sciences of the United States of America 111: 2367-2372

_____________________________________________________________________________________________________

• Ramírez V, López A, Mauch-Mani B, Gil MJ, Vera P (2013)

An Extracellular Subtilase Switch for Immune Priming in Arabidopsis

PLoS Pathogens 9: e1003445

______________________________________________________________________________________________________

• García-Andrade J, Ramírez V, López A, Vera P (2013)

Mediated Plastid RNA Editing in Plant Immunity

PLoS Pathogens 9: e1003713

_____________________________________________________________________________________________________

• Castello MJ, Carrasco JL, Navarrete-Gomez M, Daniels J, Vera P (2011)

A plant small polypeptide is a novel component of DNA-binding protein phosphatase 1 (DBP1)-mediated resistance to Plum pox virus in Arabidopsis

Plant Physiology 157: 2206-2215

___________________________________________________________________________________________________

• Garcia-Andrade J, Ramirez V, Flors V, Vera P (2011)

Arabidopsis ocp3 mutant reveals a potentiation mechanism linking ABA and JA for pathogen-induced callose deposition

Plant Journal 67: 783-794

____________________________________________________________________________________________________

• Ramirez V, Garcia-Andrade J, Vera P (2011)

Enhanced disease resistance to Botrytis cinerea in myb46 Arabidopsis plants is associated to an early downregulation of CesA genes

Plant Signaling & Behavior 66: 1-3

___________________________________________________________________________________________________

• Ramirez V, Agorio A, Coego A, Garcia-Andrade J, Hernandez MJ, Balaguer B, Ouwerkerk P, Zarra I, Vera P (2011)

MYB46 Modulates Disease Susceptibility to Botrytis cinerea in Arabidopsis

Plant Physiology 115: 1920-1935

_____________________________________________________________________________________________________

• Lopez A, Ramirez V, Garcia-Andrade J, Flors V, Vera P (2011)

The RNA Polymerase V Is Required for Plant Immunity

PLoS Genetics 7: e1002434

______________________________________________________________________________________________________

• Castello MJ, Carrasco JL, Vera P (2010)

DNA-binding protein phosphatase AtDBP1 mediates susceptibility to two potyviruses in Arabidopsis

Plant Physiology 153: 1521-1525

______________________________________________________________________________________________________

• Ramírez V, Van der Ent S, García-Andrade J, Coego A, Pieterse CMJ, Vera P (2010)

OCP3 is an important modulator of NPR1-mediated jasmonic acid-dependent induced defenses in Arabidopsis

BMC Plant Biology 10: 199

______________________________________________________________________________________________________

• Ramirez V, Coego A, Lopez A, Agorio A, Flors V, Vera P (2009)

A disease resistance regulator determines drought tolerance in Arabidopsis

Plant Journal 58: 578-591

______________________________________________________________________________________________________

• Flores-Perez U, Perez-Gil J, Rodriguez-Villalon A, Gil M-J, Vera P, Rodriguez-Concepción M (2008)

Contribution of hydroxymethylbutenyl diphosphate synthase to carotenoid buisynthesis in bacteria and plants

Biochemical and Biophysical Research Communications 371: 510-514

______________________________________________________________________________________________________

• Trujillo lE, Sotolongo M, Menéndez C, Ochogavía M, Coll Y, Hernández I, Borrás O, Thomma BPHJ, Vera P, Hernández L (2008)

SodERF3, a novel sugarcane Ethylene Responsive Factor (ERF) enhances salt and drought tolerance when over-expressed in tobacco plants

Plant Cell Physiology 2008: 512-525

_____________________________________________________________________________________________________

• Agorio A, Vera P (2007)

ARGONAUTE 4 is required for resistance to Pseudomonas syringae in Arabidopsis

Plant Cell 19: 3778-3790

______________________________________________________________________________________________________

• Carrasco JL, Castelló MJ, Vera P (2006)

14-3-3 mediates transcriptional regulation by modulating nucleo-cytoplasmic shuttling of tobacco DNA-binding protein phosphatase-1

Journal of Biological Chemistry 281: 22875-22881

______________________________________________________________________________________________________

• X Deng X, Phillips J, Bräutigam A, Engström P, Johannesson H, Ouwerkerk PBF, Ruberti I, Salinas J, Vera P, Iannacone R, Meyer AH, Bartels D (2006)

A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses

Plant Molecular Biology 61: 469-489

______________________________________________________________________________________________________

• Kolade OO, Bamford VA, Ancillo G, Jones jD, Vera P, Hemming A (2006)

In vitro characterization of the cysteine-rich capping domains in a plant leucine rich repeat protein

Biochimica et Biophysica Acta 1764: 1043-1053

______________________________________________________________________________________________________

• Carrasco JL, Ancillo G, Castello MJ, Vera P (2005)

A novel DNA-binding motif hallmark of a new family of plant transcription factors

Plant Physiology 137: 602-606

______________________________________________________________________________________________________

• Coego A, Ramirez V, Gil MJ, Flors V, Mauch-Mani B, Vera P (2005)

An Arabidopsis homeodomain transcription factor OCP3 mediates resistance to infection by necrotrophic pathogens

Plant Cell 17: 2123-2137

______________________________________________________________________________________________________

• Gil MJ, Coego A, Mauch-Mani B, Jorda L, Vera P (2005)

The Arabidopsis csb3 Mutant Reveals a Regulatory Link Between Salicylic Acid-mediated Disease Resistance and the Methyl-Erythritol 4-Phosphate Pathway

Plant Journal 44: 155-166

______________________________________________________________________________________________________

• Coego A, Ramirez V, Ellul P, Mayda E, Vera P (2005)

The H2O2-regulated Ep5C Gene Encodes a Peroxidase Required for Bacterial Speck Susceptibility in Tomato

Plant Journal 42: 283-293

______________________________________________________________________________________________________

• Carrasco JL, Ancillo G, Vera P (2005)

Transcriptional regulation of gene expression in plants: a box full of surprises

Recent Research Developments in Plant Molecular Biology 2: 63-82

______________________________________________________________________________________________________

• Carrasco JL, Ancillo G, Mayda E, Vera P (2003)

A novel transcription factor involved in plant defense endowed with protein phosphatase activity

EMBO Journal 22: 1-9

_____________________________________________________________________________________________________

• Golldack D, Vera P, Dietz KJ (2003)

Expression of subtilisin-like serine proteases in Arabidopsis thaliana is cell-specific and responds to jasmonic acid and heavy metals with developmental differences

Physiol Plantarum 118: 64-73

______________________________________________________________________________________________________

• Mayda E, Mauch-Mani B, Vera P (2000)

The Arabidopsis dth9 mutant is compromised in systemic acquired resistance without affecting SA-dependent responses

Plant Cell 12: 2119-2128

______________________________________________________________________________________________________