Jose Gadea is Principal Investigator at the IBMCP since 2009, when he got a permanent position at the Polytechnic University of Valencia. He studied Biology at the University of Valencia and got a PhD in 1997 by his studies on new genes involved in oxidative stress responses in plant-pathogen interactions. After his postdoctoral stay in 1999-2001 at University of Tübingen (Germany) and CNRS in Perpignan (France), working on genes involved in Arabidopsis early embryogenesis, he was recruited by the Citrus Functional Genomics Project at the IBMCP, to develop genomic tools for the study of issues relevant for citriculture. This pioneering project in Spain developed pipelines for high-throughput generation of expressed-sequence tags and generating the first citrus microarrays. Based on this background, his current lines of research focus in the use of molecular and genomic approaches to decipher biological problems in plants, most of them related to response to biotic and abiotic stresses. In particular, his group has two main lines of research: a) Seed science: understanding how seeds are developed, how they perceive environmental stimuli and why they deteriorate and die. b) Plant-pathogen interactions: understanding the mode of action in plant tissues of Xanthomonas citri and Candidatus Liberibacter, two bacteria that cause disease which results in heavy economic losses to the citrus industry.
Joan Renard, Irene Martínez-Almonacid, Indira Queralta Castillo, Annika Sonntag, Aseel Hashim, Gaetano Bissoli, Laura Campos, Jesús Muñoz-Bertomeu, Regina Niñoles, Thomas Roach, Susana Sánchez-León, Carmen V. Osuna, José Gadea, Purificación Lisón, Ilse Kranner, Francisco Barro, Ramón Serrano, Isabel Molina, Eduardo Bueso. Apoplastic lipid barriers regulated by conserved homeobox transcription 2 factors extend seed longevity in multiple plant species. New Phytologist (2021). Jul;231(2):679-694
Isabel Faus, R. Niñoles, V. Kesari & J. Gadea.The ABCF3 Gene of Arabidopsis Is Functionally Linked with GCN1 but Not with GCN2 During Stress and Development, 2021. Plant Mol Biol Rep (2021). https://doi.org/10.1007/s11105-021-01283-w
Renard J, Niñoles R, Martínez-Almonacid I, Gayubas B, Mateos-Fernández R, Bissoli G, Bueso E, Serrano R, Gadea J. Identification of novel seed longevity genes related to oxidative stress and seed coat by genome-wide association studies and reverse genetics. Plan Cell and Environment 2020 Oct;43(10):2523-2539. doi: 10.1111/pce.13822.
Renard, Joan; Martínez-Almonacid, Irene; Sonntag, Annika; Molina, Isabel; Moya-Cuevas, José; Bissoli, Gaetano; Munoz-Bertomeu, Jesus; Faus, Isabel; Niñoles, Regina; Shigeto, Jun; Tsutsumi, Yuji; Gadea, Jose; Serrano, Ramon; Bueso, Eduardo. Peroxidases regulate the polyphenolics spectrum in seed coats to increase seed longevity. Plan Cell and Environment, 2020 Feb;43(2):315-326. doi: 10.1111/pce.13656.
Favaro MA, Molina MC, Roeschlin RA, Gadea J, Gariglio N, Marano MR. Differen Responses in Mandarin Cultivars Uncover a Role of Cuticular Waxes in the Resistance to Citrus Canker, Phytopathology, 2020, Nov;110(11):1791-1801 CLAVE: A
de Luis B, Llopis-Lorente A, Rincón P, Gadea J, Sancenon F, Aznar E, Villalonga R, Murguía JR, Martínez-Máñez R. An Interactive Model of Communication between Abiotic Nanodevices and Living Microorganisms. Angew Chem Int Ed Engl. 2019 doi: 10.1002/anie.201908867
Roeschlin RA, Uviedo F, García L, Molina MC, Favaro MA, Chiesa MA, Tasselli S, Franco-Zorrilla JM, Forment J, Gadea J*, Marano MR*. PthA4(AT) , a 7.5-repeats transcription activator-like (TAL) effector from Xanthomonas citri ssp. citri, triggers citrus canker resistance. Molecular Plant Pathology. 2019 Jul 5. doi:10.1111/mpp.12844.
Paula Llabata, Julia Richter, Isabel Faus, Karolina M. Slominska-Durdasiak, Lukas H. Zeh, Jose Gadea, Marie-Theres Hauser. Involvement of the eIF2a kinase GCN2 in UV-B responses 2019 Frontiers in Plant Sciences, Nov 28;10:1492. doi: 10.3389/fpls.2019.01492.
Chiesa MA, Roeschlin RA, Favaro MA, Uviedo F, Campos-Beneyto L, D’Andrea R,Gadea J, Marano MR. Plant responses underlying nonhost resistance of Citrus limon against Xanthomonas campestris pv. Campestris. Mol Plant Pathol. 2018 Sep 27.
Faus I, Niñoles R, Kesari V, Llabata P, Tam E, Nebauer SG, Santiago J, Hauser MT, Gadea J. Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation. Journal Plant Physiology. 2018 May – Jun;224-225:173-182.
Roeschlin RA, Favaro MA, Chiesa MA, Alemano S, Vojnov AA, Castagnaro AP, Filippone MP, Gmitter FG Jr, Gadea J*, Marano MR*. Resistance to citrus canker induced by a variant of Xanthomonas citri ssp. citri is associated with a hypersensitive cell death response involving autophagy-associated vacuolar processes. Mol Plant Pathol. 2017 Sep 20. doi: 10.1111/mpp.12489.
Amil-Ruiz F, Garrido-Gala J, Gadea J, Blanco-Portales R, Muñoz-Mérida A, Trelles O, de Los Santos B, Arroyo FT, Aguado-Puig A, Romero F, Mercado JÁ, Pliego-Alfaro F, Muñoz-Blanco J, Caballero JL. Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction. Frontiers in Plant Sciences. 2016 Jul 15;7:1036
Faus I, Zabalza A, Santiago J, Nebauer SG, Royuela M, Serrano R, Gadea J. Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis. BMC Plant Biol. 2015 Jan 21;15:14. doi: 10.1186/s12870-014-0378-0.